Translate

BUY NOTES

BUY NOTES
Radiotherapy लेबलों वाले संदेश दिखाए जा रहे हैं. सभी संदेश दिखाएं
Radiotherapy लेबलों वाले संदेश दिखाए जा रहे हैं. सभी संदेश दिखाएं

interaction of radiation with matter

interaction of radiation with matter

 When X-rays and gamma-rays fall on an object, some of those photons interact with particles (electrons, protons) of matter, and their energy is either absorbed or scattered. This absorption or scattering of photon is called attenuation. The remaining photons go straight from the particle of any matter without interacting with it.

The number of photons that transmit from a material depends on the thickness, density, atomic number of the material and the energy of each photon.

There is a possibility of four types of reaction when there is an interaction with the matter of an ionizing radiation.

interaction of radiation with matter


  1. COHERENT SCATTERING -Radiography / Radiotherapy in ......... Read More
  2. PHOTOELECTRIC EFFECT - It's an all or none ........ Read More
  3. COMPTON EFFECT- Photon in this effect .......... Read More
  4. PAIR PRODUCTION- It is in an energy mass ....... Read More

These four effects lead to the following conclusion -


When absorption is through the photoelectric effect, bone absorbs more energy than soft tissue (up to 6 times more).

Bone and soft tissue per gram absorb the same energy in the case of the Compton effect.

If absorption is only through Pair production, Bone absorbs twice as much energy than Soft Tissue.

Energy effect

UP to 50 keV Photo Electric Effect

60-90 KeV Photo Electric Effect + Compton Effect

200KeV-2 MeV Compton Effect

5 MeV-10 MeV Pair Production begins to important

50 MeV-100 MeV Pair Production most important

pair production in radiotherapy

pair production

 Energy का mass में conversion ही एक pair production का उदाहरण हैं। 1.02 MeV इसके लिए threshold energy होती हैं। जब threshold energy वाला  photon nucleus के field के पास आता है तो यह गायब हो जाता हैं। जिसके कारण electron positron pair produce होता हैं। इसी प्रभाव को pair production कहते है।

pair production


 electron positron pair को उत्पन्न करने के लिए 1.02 MeV energy का उपयोग होता हैं तथा दोनों particles में शेष ऊर्जा समान रूप से स्थानांतरित हो जाती हैं। जिससे एक दूसरे  के opposite direction में दोनों ओर गति करते है।

 हालांकि 1.02 MeV threshold energy होती है pair production के लिए लेकिन दोनों particle को kinetic energy देने के लिए पर्याप्त energy न हो तो यह तब नही पाया जाता हैं। साधारणतः pair production 2 Mev से कम energy पर नही पाया जाता हैं। atomic number (z) पर pair production निर्भर करता है।

Pair Production ∝ Z2

equivalent dose in radiology

equivalent dose in radiology

However , the absorbed dose in a medium for all ionizing radiation is measured in energy joules per kilogram ( J / kg ) absorbed by per unit mass But the biologiacl effect produced by the same or equivalent dose of different types of radiation is  not the same. 

equivalent dose in radiology



     This is due to the difference in the specific ionization that occurs in the medium due to the difference in the biological effect generated by different radiation Due to different radiation, specific ionization in the medium varies.

A separate unit sievert (Sv) was defined to detect the biologic effect generated by ionizing radiation.  
1 Sievert = 1J / kg
   The dose that produces the biological effect is called Equivalent dose. Sievert is a unit of dose measurement. In the case of this equivalent dose of radiotherapy, it is important for radiation protection. Its Conventional Unit, is Rem.

High ICRP has proposed a radiation weighting factor (Wr) to show the relationship between equivalent       dose and Absorbed dos e. This shows the relative effectiveness of the dose of radiation causing biological damage. 
The  product of absorbed dos e and  radiation weighting factor is   called Equivalent dose . 
Dose equivalent (rem) = Wr X rad
If absorbed dose is displayed in Gy, equivalent dose is displayed in sievert. 
Sv = Wr X Gy
     Wr is a dimensionless or dimensionless  amount and  depends on the LET . Wr is 1 for X-ray and Gamma ray. The value of Wr for Thermal neutron is 5. The value of Wr is 20 for fast neutron and heavy particle (ɑ-particle). High LET radiation can cause more biological damage , so their Wr is more. 

Kinetic Energy Release In Medium ( KERMA )

kinetic energy release in medium ( KERMA )

Initial interaction of an X-Ray photn in a medium is  called KERMA. When X and 4-rays pass through a medium, they transfer their kinetic energy to the charged particle electrons and protons. KERMA (K)  refers to the energy transferred to the charged particle. This charge trajectory forward into the particle medium

Kinetic Energy Release In Medium ( KERMA )



During the process, some electrons interact with the atom to produce Bremsstrahlung Radiaiton and some electrons react with another electron to produce 𝛅-rays. In the human body, only Bremsstrahlung is significant,  the amount of rays-rays is very small, so it is ignored. Its unit is joule / kg (J / Kg). Its SI  Gray is | Its special unit is Rad. When the reference material is air, it is called air kerma. 


1 air kerma (Gy) = 114R

radiation exposure

radiation exposure

Exposure is the amount of ionizing photon present in a radiation beam. The amount of ionizing photon in a medium is determined by the number of ions generated by them. Air is an universal medium for measuring exposure.

A Roentgen X or Gamma is the amount of radiation through which 0.001293 grams of air-entrapped corpuscular emission can flow 1esu of any sign.

The SI unit of exposure is Roentgen (R). An exposure unit is the amount of photons that generate a coulomb charge in 1 kilogram of air. 
1R = 2.58 X 10-4 C / Kg of Air
radiation exposure


The radiation monitor device is callibrate in the zone or millimeter. The output of an x-ray machine is measured by mR / mAs. For example, a 75Kv, X-ray machine with a 2mm Al filtration gives an output of 5mR / mAs at 100cm distance.
Measurement of exposure is easier with an ionization chamber filled with air. The effective atomic number of air and soft tissue is almost the same. Therefore, the exposure measured in diagnostic X-ray energy is similar to that of soft tissue. Exposure is defined only for X-ray and gamma radiation in air.

unit of radioactivity

unit of radioactivity

The unstable nucleus number present in a radionuclide is called activity. This nucleus radio-disintegraion

Achieve stability through Radiation emanating from a radioactive material is directly related to its activity

Is proportional.

Therefore, the activity shows the amount of radiation emitted in a unit time. Its unit curie (Ci)

 It happens.

A curie denotes the disintegration per second or dissolution per second that occurs in 1 gram of radium 226.

1Ci = 3.7 X 10 10 dps
Its small units, milli curie and microcurry are also used.
1mCi = 3.7 X 10 7 dps

 

 1μCi = 3.7 X 10 4 dps

Activity of SI UNIT Becquerel is | L Becquerel Ldps equals |
1Ci = 3.7 X 10 10 dps

principle of radiation measurement

principle of radiation measurement

ionization

Radiation creates positive and negative ions in a gas or matter, this process is called Ionization. This process is caused by the release of electrons from ions or molecules. These ions which are two in number are called Ion Pair, and can be collected by applying an electric field, which is found in the form of curent or puslses. The total charge collected is proportional to radiation intensity. Generally gaseous or solid media is used for Ionization. Ionization can be used in Bq measurement and dose measurement. Ionization Chamber, Proportional Counter, Geiger-Muller (GM) Counter and Semiconductor Detector etc. fall under this category.

principle of radiation measurement
farmer chamber


Luminescence

There are some compounds that have the characteristic of emitting visible light when radiation falls. In this process, the energy of radiation is converted into visible light. This light flash is detected by a Photomultiplier tube (PMT) or Photo Diode, which generates electrical signals. These electrical signals are proportional to the intensity of radiation occurring. Detectors built on this principle are called scintillators e.g. NaI | Scintillation detectors are divided into organic compounds and inorganic crystals. 

Thermo-luminescence

Some materials have the ability to take energy from radiation and store it for long periods such as LiF and CaSO4. After heating these materials, storred energy is released as light or luminescence. The amount of light emitted is proportional to the radiation intensity incident on it. The devices based on this effect are called thermo luminescent dosimeters. 

Photographic Effect

Ionization Radiation affects the photographic film and forms a latent image in the form of density patterns. On processing this film, the optical density of the image is measured. The amount of blackness on the film is proportional to the amount of incident radiation. This film blackness is measured as optical density. 
  OD = Log10 I0 / It 
This principle is used in film dosimetery. E.g. Film badge.

Chemical Effect

Ionization Radiation can cause chemical changes in some chemicals. E.g. They oxidize ferrous sulfate to ferric sulfate. You can measure radiation dose by measuring concentration of ferric ion. Radiation also changes the color of some plastics, also measured radiation dose. These principles are useful in chemical dosimetry. 

Biological Effect

Radiation exposure can cause changes in lymphocytes and chromosomes. Exposed individual blood samples are analyzed for chromosomal aberration such as Dicentric and Ring Formation. This aberration score is a measure of radiation exposure and is called biological dosimetry. Chromosomal dicentric analysis is performed by blood samples that measure radiation doses in the range 100mSv to 6 Sv. This dosimetry is done during accidental exposure when there is no other radiation exposure information. 

Compton effect

Compton effect

In the Compton effect , the photon interacts with the free electron of the atom and gives it only some of its energy as orbit (E b ) and Kinetic Energy (K) . Incidnet photon with the remaining {Energy H𝒗 - (E B + E K )} goes in a different direction and the other atom interaction is.

Compton effect
Compton effect


This Compton electron  and Scattered photon are two products. Atomic number Z has no effect on the Compton Effect . So body in high and Low Atomic Number Maetrial position Compton effect is the same .
Therefore , in the case of cobalt gamma rays and high energy X-rays (4MV to 20MV) , energy absorption is mainly from the compton process . This Supervoltage Radiation has an advantage over Orthovoltage Radiation . As the energy increases, the energy absorption decreases due to the Compton effect , and it is proportional to 1 / E.

photo electric effect

 photo electric effect

It is an all or none phenomenon  . In this interaction , the incident photon orbit interacts with the bound electron. At this time a portion of the photon's energy is used to drive the electron (BE = E B ) out of the orbit, and the remaining energy (h𝒗 - E B ) is given to the electron as kinetic energy . 

Thus the photon disappears and a photoelectron is  generated. Thus the vacancy generated by the electron is filled by the outer shell electron and Characteristic X rays are  generated.   
As the atomic number of absorber increases, the photoelectric effect increases. 
PE ∝ Z 3
That is , the absorption of energy is higher by taking higher Z material . So in radiotherapy, Bones  absorb more energy than Soft Tissue and Muscle . So Orthovoltage Therapy for Bone Necrosis to reduce Bone Shielding is | The photoelectric effect is less effective  as the photon 's enargy increases , as more electrons behave like free electrons.

photo electric effect
photo electric effect

Note  

Bound electron

When the energy of the photon is equal to or slightly higher than that of the interating electron, it is called bound or bound electron. 

Free electron

When the energy of photon is much higher than the interacting electron, it is called free electron.

coherent scattering

coherent scattering 

This effect is not very important in Radiotheray / Radiology . When the interacting photon passes through the orbital electron of the target atom, it starts occluding. This results in the emission of a recurring energy similar to the incident photon. 

Here the incident beam is scattering without any energy loss, that is, the photon changes its direction. This phenomenon is more in the state of high atomic number and low photon energy. 
coherent scattering
coherent scattering 


Note  

Bound electron

When the energy of the photon is equal to or slightly higher than that of the interating electron, it is called bound or bound electron. 

Free electron

When the energy of photon is much higher than the interacting electron, it is called free electron.

Radiotherapy principal

When Radiation is applied from outside the body in the form of a beam, this situation is called External Beam Radiotherapy . Apart from this, Radiation can also be given by placing Rdioactive source inside the body,   says Intracavitory / Intraluminal Radiotherapy .  

In Interstitial Radiotherapy   , the  radioactive source is directly  implanted in the tissue . 
Radioactive Fluids are injected directly into the body through artery and vein in some diseases .

Aim of Radiotherapy 

Radiotherapy is usually given by the Radical or Palliative method according to the need of treatment of each patient.

Radical Treatment 

Radical treatment , given in a planned manner to a patient to cure his disease , is called radical treatment. Treatment of such a patient includes a tumor in the tratment area and the area around it where microscopic disease is  present. In this type of treatment, the radiation beam is applied to the tumor from more than one direction, and sometimes more than one type of radiotherapy (eg Teletherapy or Brachytherapy ) is used. The radiation dose given in it is very high, which also has side effects, but these side effects are acceptable for treatment. 

Palliative Treatment

The purpose of palliative radiotherapy is to relieve the patient from symptoms caused by advanced cancer, such as in most lung cancer  , this treatment is simpler  than the radical treatment , and it is given for a short time. In palliative treatment, the patient is given a low dose for a short time, so that minimal side effects are produced. 

How is Radiotherapy Administered

The radiotherapy machine that generates radiation has the characteristic that it can align the tumor of the patient in the radiation emitting side properly. External beam radiotherapy consists of a light field, which mimic like a radiation field, and at the same time marks are placed on the surface of the patient, which determines the field to be applied to the radiation beam, so that the surface of the body And the deep tumor can be cured.
Brachytherapy consists of a guide tube through which the radiation source is inserted into the body cavity or tissue, and this radioactive source is removed after treatment. Radiotherapy Treatment , Radiotherapist is determined by |
Each course of treatment is given a different number of fractions or doses , and each is given on a certain day. Generally, a fraction is given each day in radiotherapy. Treatment start  before t
issue is taken to localize and is calculated as a suitable treatment schedule, which Radiotherapy Treatment Planning says | By this, it is ensured that the planned treatment is given accurate to the tumor. That radiotherapy treatment  and therapeutic radiography base  is.

Radiotherapy treatment option

Patient his malignant disease in several types of radiotherapy treatment option are | A patient  can be treated by one or more treatment modality . Second Assistant ( Adjuvant ) therapy such as Chemotherapy and radiotherapy can be inserted (combine) with .
External beam X-rays of varying energy are used in most radiotherapy treatment . For which many types of machines are available, in some departments electron beam is also used for treatment. For certain purposes, such a machine is used for the treatment of gamma-rays.Generates radioactive isotope . Besides external beam particle therapy  is also used for the treatment of |